METHOTREXATE

Q94C74 — Serine hydroxymethyltransferase 2, mitochondrial

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB00563

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand DB00563

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
Q94C74	DB00563	6smn	MTX	A	603	e6smnA1	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	A	603	e6smnA2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	A	603	e6smnB2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	A	603	e6smnD1	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	B	2404	e6smnA1	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	B	2404	e6smnA2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	B	2404	e6smnB1	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	B	2404	e6smnB2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	B	2404	e6smnC2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	C	617	e6smnA1	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	C	617	e6smnA2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	C	617	e6smnC2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	C	617	e6smnD1	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
Q94C74	DB00563	6smn	MTX	C	617	e6smnD2	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT