2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide

Q96SW2 — Protein cereblon

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand V4M

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
Q96SW2	None	V4M	001320693	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
Q96SW2	None	V4M	001763945	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C

Show other predicted domains (32)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
4TZ4	e4tz4C2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
5FQD	e5fqdE2	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e5fqdB1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
	e5fqdE1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
5HXB	e5hxbZ1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e5hxbC2	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e5hxbZ2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
	e5hxbC1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
5V3O	e5v3oC2	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
5V3O	e5v3oC1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
6BN7	e6bn7B1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
6BN7	e6bn7B2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
6BN8	e6bn8B2	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
6BN8	e6bn8B1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
6BN9	e6bn9B1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
6BN9	e6bn9B2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
6BNB	e6bnbB1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
6BNB	e6bnbB2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
6BOY	e6boyB2	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
6BOY	e6boyB1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
6H0F	e6h0fB1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e6h0fE1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e6h0fH2	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e6h0fK1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e6h0fB2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
	e6h0fE2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
	e6h0fH1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
	e6h0fK2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
6H0G	e6h0gB2	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e6h0gE1	1.1.9	cradle loop barrel	RIFT-related	PUA domain	TruB_C
	e6h0gB1	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP
	e6h0gE2	708.1.2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	TCTP

ECOD domains from experimental PDB structures interacting with ligand V4M

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
Q96SW2	n/a	6xk9	V4M	C	501	e6xk9C1	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	Yippee-Mis18
Q96SW2	n/a	6xk9	V4M	C	501	e6xk9C2	cradle loop barrel	RIFT-related	PUA domain	LON_substr_bdg
Q96SW2	n/a	6xk9	V4M	Z	501	e6xk9Z1	cradle loop barrel	RIFT-related	PUA domain	LON_substr_bdg
Q96SW2	n/a	6xk9	V4M	Z	501	e6xk9Z2	ETN0001 domain-like	ETN0001 domain-like	Mss4-like	Yippee-Mis18