[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

Q9UHD2 — Serine/threonine-protein kinase TBK1

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB12010

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
Q9UHD2	DB12010	2RC	nD1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase, ABC1, Pkinase_fungal
Q9UHD2	DB12010	2RC	nD3	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1

Show other predicted domains (68)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
4EFO	e4efoA1	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
4EFO	e4efoB1	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
4EUT	e4eutB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4eutA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4eutB2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4eutA1	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
4EUU	e4euuA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
4EUU	e4euuB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
4IM0	e4im0A3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4im0A2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4im0A4	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
4IM2	e4im2A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4im2A3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4im2A5	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
4IM3	e4im3A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4im3A3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4im3A2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
4IW0	e4iw0A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4iw0A3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4iw0A2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
4IWO	e4iwoA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4iwoA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4iwoA5	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
4IWP	e4iwpA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4iwpA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4iwpA5	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
4IWQ	e4iwqA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4iwqA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4iwqA5	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
5W5V	e5w5vA3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e5w5vA2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e5w5vA1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6BNY	e6bnyA3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6bnyA2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6bnyA1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6BOD	e6bodA3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6bodA2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6bodA1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6BOE	e6boeA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6boeA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6boeA1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6CQ0	e6cq0A2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6cq0A1	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6cq0A3	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6CQ4	e6cq4A3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6cq4A1	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6cq4A2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6CQ5	e6cq5A2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6cq5A1	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6cq5A3	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6NT9	e6nt9A3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6nt9B3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6nt9A2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6nt9B2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6nt9A1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e6nt9B1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6O8B	e6o8bA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6o8bB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6o8bA2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6o8bB2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6o8bA3	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e6o8bB3	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6RSR	e6rsrA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6rsrA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6rsrA1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
6RST	e6rstA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6rstA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e6rstA1	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1

ECOD domains from experimental PDB structures interacting with ligand DB12010

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
No experimental ECOD data found