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N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide

P15056 — Serine/threonine-protein kinase B-raf

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Attributes

UniProt ID
P15056
Protein Name
Serine/threonine-protein kinase B-raf
Ligand Name
N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide
DrugBank ID
DB08881
PDB Ligand Accession
032
ChEMBL ID
CHEMBL1229517
PubChem ID
42611257
InChIKey
GPXBXXGIAQBQNI-UHFFFAOYSA-N
SMILES
CCCS(=O)(=O)Nc1ccc(c(c1F)C(=O)c2c[nH]c3c2cc(cn3)c4ccc(cc4)Cl)F
Drug Action
inhibitor
Affinity Metrics
ic50:4 nM
kd:10 nM
ec50:601 nM