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2-[1-[(3~{S})-6'-azanyl-5'-cyano-7-fluoranyl-2,2,3'-trimethyl-spiro[1~{H}-indene-3,4'-2~{H}-pyrano[2,3-c]pyrazole]-5-yl]piperidin-4-yl]ethanoic acid

A0A1G4H5I1 — glycine hydroxymethyltransferase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 8UF

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 8UF

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
A0A1G4H5I1n/a5yg48UFA502e5yg4A1C-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesSHMT
A0A1G4H5I1n/a5yg48UFA502e5yg4A2PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A0A1G4H5I1n/a5yg48UFA502e5yg4B1PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A0A1G4H5I1n/a5yg48UFB502e5yg4A2PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A0A1G4H5I1n/a5yg48UFB502e5yg4B1PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A0A1G4H5I1n/a5yg48UFB502e5yg4B2C-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesSHMT
A0A1G4H5I1n/a5yg48UFC502e5yg4C1PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A0A1G4H5I1n/a5yg48UFC502e5yg4C2C-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesSHMT