METHOTREXATE

O23254 — Serine hydroxymethyltransferase 4

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB00563

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand DB00563

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
O23254	DB00563	6smr	MTX	A	503	e6smrA1	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	A	503	e6smrA2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	A	503	e6smrB1	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	A	503	e6smrB2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	B	501	e6smrA1	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	B	501	e6smrA2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	B	501	e6smrB2	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	D	703	e6smrC1	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	D	703	e6smrD1	PLP-dependent transferases	PLP-dependent transferases	PLP-dependent transferases	SHMT
O23254	DB00563	6smr	MTX	D	703	e6smrD2	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	C-terminal domain in some PLP-dependent transferases	SHMT