1-[(3'S)-6-chloro-1'-(isoquinolin-4-yl)-1,2'-dioxo-1H-spiro[isoquinoline-4,3'-pyrrolidin]-2(3H)-yl]-N-methylcyclopropane-1-carboxamide

P0DTD1 — Replicase polyprotein 1ab

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand RZU

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand RZU

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P0DTD1	n/a	7gnj	RZU	A	407	e7gnjA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7gnj	RZU	A	407	e7gnjA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnj	RZU	A	407	e7gnjB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnj	RZU	B	404	e7gnjA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnj	RZU	B	404	e7gnjB1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7gnj	RZU	B	404	e7gnjB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnr	RZU	A	408	e7gnrA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7gnr	RZU	A	408	e7gnrA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnr	RZU	A	408	e7gnrB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnr	RZU	B	404	e7gnrA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnr	RZU	B	404	e7gnrB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gnr	RZU	B	404	e7gnrB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30