(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE

P11387 — DNA topoisomerase 1

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB00762

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
P11387	DB00762	CP0	nD3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Topoisom_I
P11387	DB00762	CP0	nD5	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Topoisom_I,Topo_C_assoc

Show other predicted domains (69)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
1A31	e1a31A5	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1a31A6	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1a31A3	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1a31A7	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1A35	e1a35A2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1a35A3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1a35A1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1a35A4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1A36	e1a36A2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1a36A3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1a36A5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1a36A1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1a36A4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1EJ9	e1ej9A2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1ej9A3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1ej9A1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1ej9A4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1K4S	e1k4sA2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1k4sA3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1k4sA1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1k4sA4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1K4T	e1k4tA2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1k4tA3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1k4tA5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1k4tA1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1k4tA4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1LPQ	e1lpqA2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1lpqA3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1lpqA5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1lpqA1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1lpqA4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1NH3	e1nh3A2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1nh3A5	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1nh3A1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1nh3A4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1R49	e1r49A2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1r49A3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1r49A5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1r49A1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1r49A4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1RR8	e1rr8C5	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1rr8C6	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1rr8C8	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1rr8C7	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1RRJ	e1rrjA2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1rrjA3	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1rrjA5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1rrjA1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1rrjA4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1SC7	e1sc7A2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1sc7A4	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1sc7A5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1sc7A3	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1sc7A1	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1SEU	e1seuA2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1seuA6	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1seuA5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1seuA1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1seuA4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1T8I	e1t8iA2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1t8iA6	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1t8iA5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1t8iA1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1t8iA4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
1TL8	e1tl8A2	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1tl8A6	101.1.8	HTH	HTH	DNA breaking-rejoining enzymes	Phage_integrase
	e1tl8A5	192.8.1	Long alpha-hairpin	Eukaryotic DNA topoisomerase I, dispensable insert domain	Eukaryotic DNA topoisomerase I, dispensable insert domain	Tropomyosin
	e1tl8A1	4039.1.1	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N
	e1tl8A4	4057.1.1	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Topoisom_I_N

ECOD domains from experimental PDB structures interacting with ligand DB00762

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
No experimental ECOD data found