DrugDomain logoDrugDomain

(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE

P11387 — DNA topoisomerase 1

← Back

Attributes

UniProt ID
P11387
Protein Name
DNA topoisomerase 1
Ligand Name
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE
DrugBank ID
DB01030
PDB Ligand Accession
TTC
ChEMBL ID
CHEMBL84
PubChem ID
60700
InChIKey
UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES
CCC1(C2=C(COC1=O)C(=O)N3Cc4cc5c(ccc(c5CN(C)C)O)nc4C3=C2)O
Drug Action
inhibitor
Affinity Metrics
ic50:21 nM
kd:26.5 nM
ec50:54 nM