[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

P42345 — Serine/threonine-protein kinase mTOR

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB12010

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
P42345	DB12010	2RC	nD2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	mTOR_dom
P42345	DB12010	2RC	nD5	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	FAT, HEAT_ATR
P42345	DB12010	2RC	nD7	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
P42345	DB12010	2RC	nD8	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	PI3_PI4_kinase,FATC

Show other predicted domains (76)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
1AUE	e1aueB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
1AUE	e1aueA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
1FAP	e1fapB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
1NSG	e1nsgB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
2FAP	e2fapB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
2GAQ	e2gaqA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
2NPU	e2npuA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
2RSE	e2rseB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
3FAP	e3fapB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
3JBZ	e3jbzA1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
3JBZ	e3jbzA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
4DRH	e4drhE1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4DRH	e4drhB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4DRI	e4driB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4DRJ	e4drjB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4FAP	e4fapB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4JSN	e4jsnA2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jsnB3	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jsnA3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jsnB4	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jsnA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e4jsnB2	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4JSP	e4jspA2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jspB3	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jspA3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jspB4	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jspA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e4jspB2	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4JSV	e4jsvB2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jsvA2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jsvB3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jsvA3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jsvB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e4jsvA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4JSX	e4jsxB2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jsxA2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jsxB3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jsxA3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jsxB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e4jsxA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4JT5	e4jt5B2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jt5A2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jt5B3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jt5A3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jt5B1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e4jt5A1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
4JT6	e4jt6B2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jt6A2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e4jt6B3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jt6A3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4jt6B1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e4jt6A1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
5FLC	e5flcB1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e5flcF2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e5flcB3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e5flcF1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e5flcB2	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e5flcF3	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
5GPG	e5gpgB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
5WBH	e5wbhA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e5wbhB1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e5wbhC1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e5wbhD1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e5wbhE1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
5WBU	e5wbuB2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e5wbuA3	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e5wbuB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e5wbuA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e5wbuB3	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e5wbuA1	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
5WBY	e5wbyB3	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e5wbyA2	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
	e5wbyB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e5wbyA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e5wbyB2	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom
	e5wbyA3	601.24.1	Four-helical up-and-down bundle	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	FRB_dom

ECOD domains from experimental PDB structures interacting with ligand DB12010

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
No experimental ECOD data found