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1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide

Q15910 — Histone-lysine N-methyltransferase EZH2

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 74D

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 74D

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
Q15910n/a5ls674DA809e5ls6A2Ezh2 N-terminal domainEzh2 N-terminal domainEzh2 N-terminal domainEZH2_WD-Binding
Q15910n/a5ls674DA809e5ls6A3beta-clipSET domain-likeSET domain-likeSET
Q15910n/a5ls674DD809e5ls6D1beta-clipSET domain-likeSET domain-likeSET
Q15910n/a5ls674DD809e5ls6D3Ezh2 N-terminal domainEzh2 N-terminal domainEzh2 N-terminal domainEZH2_WD-Binding
Q15910n/a5ls674DG809e5ls6G1Ezh2 N-terminal domainEzh2 N-terminal domainEzh2 N-terminal domainEZH2_WD-Binding
Q15910n/a5ls674DG809e5ls6G5HTHHTHThree-helical HTHPRC2_HTH_1
Q15910n/a5ls674DG809e5ls6G6beta-clipSET domain-likeSET domain-likeSET
Q15910n/a5ls674DJ809e5ls6J4Ezh2 N-terminal domainEzh2 N-terminal domainEzh2 N-terminal domainEZH2_WD-Binding
Q15910n/a5ls674DJ809e5ls6J7beta-clipSET domain-likeSET domain-likeSET