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7-[4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL] -3,5-DIHYDROXY-HEPTANOIC ACID

P04035 — 3-hydroxy-3-methylglutaryl-coenzyme A reductase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB01098

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand DB01098

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
P04035DB010981hwlFBIA2e1hwlA1Alpha-beta plaitsHMG-CoA reductaseNAD-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIA2e1hwlA2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIA2e1hwlB2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIB1e1hwlA2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIB1e1hwlB1Alpha-beta plaitsHMG-CoA reductaseNAD-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIB1e1hwlB2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIC4e1hwlC1Alpha-beta plaitsHMG-CoA reductaseNAD-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIC4e1hwlC2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBIC4e1hwlD2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBID3e1hwlC2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBID3e1hwlD1Alpha-beta plaitsHMG-CoA reductaseNAD-binding domain of HMG-CoA reductaseHMG-CoA_red
P04035DB010981hwlFBID3e1hwlD2Alpha-beta plaitsHMG-CoA reductaseSubstrate-binding domain of HMG-CoA reductaseHMG-CoA_red