Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
P00374 DYR_HUMAN
Gene name: DHFR
Protein name: Dihydrofolate reductase (EC

List of molecules and drugs that interact with protein P00374

# DrugDomain Data PBD ligand DrugBank Accession PubChem ChEMBL Name Drug action Affinity data
1 P00374_06U 06U n/a 56955942 CHEMBL4483572 6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine n/a
2 P00374_1QZ 1QZ n/a 71737835 n/a 6-ethyl-5-{(3S)-3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine n/a
3 P00374_1R0 1R0 n/a 71560296 CHEMBL2335420 6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine n/a
4 P00374_21V 21V DB04322 445072;5288680;135409836; n/a N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid n/a
5 P00374_25U 25U n/a 71737834 CHEMBL3644523 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine n/a
6 P00374_34B 34B n/a n/a n/a 2,4-DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE n/a
7 P00374_39B 39B n/a n/a n/a (S)-2,4-DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6-METHYLPYRIMIDINE n/a
8 P00374_3TU 3TU n/a 52914861 CHEMBL1738740 (2S)-2-(5-{[(2-amino-4-oxo-3,4-dihydro[1]benzothieno[2,3-d]pyrimidin-5-yl)methyl]amino}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid n/a
9 P00374_3TZ 3TZ n/a 52914860 CHEMBL1738741 N-[(4-{[(2-amino-4-oxo-3,4-dihydro[1]benzothieno[2,3-d]pyrimidin-5-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid n/a
10 P00374_4RI 4RI n/a 9881905 CHEMBL416552 6-hexyl-5-phenyl-pyrimidine-2,4-diamine n/a
11 P00374_51P 51P n/a 11687971 CHEMBL606039 5-[(1Z)-2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine n/a
12 P00374_63W 63W n/a 124037101 n/a 5-methyl-6-{[4-(trifluoromethyl)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine n/a
13 P00374_63Y 63Y n/a 124037103 n/a 5-methyl-6-[(2,3,4-trifluorophenyl)sulfanyl]thieno[2,3-d]pyrimidine-2,4-diamine n/a
14 P00374_64J 64J n/a 124037104 n/a 5-methyl-6-{[4-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine n/a
15 P00374_65H 65H n/a 124080838 CHEMBL4226465 6-[(4-methoxyphenyl)sulfanyl]-5,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine n/a
16 P00374_65J 65J n/a 124080837 CHEMBL4227124 7-ethyl-6-[(3-methoxyphenyl)sulfanyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine n/a
17 P00374_65N 65N n/a 124080840 n/a N~6~-methyl-N~6~-[4-(trifluoromethoxy)phenyl]pyrido[3,2-d]pyrimidine-2,4,6-triamine n/a
18 P00374_65O 65O n/a 124080841 n/a 5-methyl-6-(naphthalen-1-ylsulfanyl)thieno[2,3-d]pyrimidine-2,4-diamine n/a
19 P00374_65Q 65Q n/a 137348431 n/a 5-methyl-6-{[3-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine n/a
20 P00374_684 684 n/a 11442756 CHEMBL430821 4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid n/a
21 P00374_9DR 9DR n/a 57149550 CHEMBL3219804 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine n/a
22 P00374_9QO 9QO n/a 50992060 CHEMBL4442735 5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine n/a
23 P00374_9QR 9QR n/a 60199138 CHEMBL4462726 5-(4-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine n/a
24 P00374_CA CA n/a 271 n/a CALCIUM ION n/a
25 P00374_CD CD n/a 31193 n/a CADMIUM ION n/a
26 P00374_CL CL n/a 312 n/a CHLORIDE ION n/a
27 P00374_CO4 CO4 DB02104 447815 CHEMBL50514 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE n/a
28 P00374_COP COP DB06178 130731 CHEMBL590985 N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID n/a
29 P00374_D2B D2B n/a 44246320 n/a 5-[(1Z)-2-(2-methoxyphenyl)-3-methylbut-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine n/a
30 P00374_D2D D2D n/a 49795046 n/a 5-[(1E)-2-(2-methoxyphenyl)-4-methylpent-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine n/a
31 P00374_D2E D2E n/a 49866880 n/a 5-[(E)-2-cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine n/a
32 P00374_D2F D2F n/a 49866881 n/a 5-[(1E)-2-(2-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine n/a
33 P00374_D2H D2H n/a 49866882 n/a 5-[(1E,3R)-2-(2-methoxyphenyl)-3-methylpent-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine n/a
34 P00374_D2Q D2Q n/a 49866884 n/a ethyl 5-{2-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}pentanoate n/a
35 P00374_DH1 DH1 n/a 490573 CHEMBL37520 2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE n/a
36 P00374_DMS DMS DB01093 679 CHEMBL504 DIMETHYL SULFOXIDE n/a
37 P00374_DTM DTM DB02919 447229 CHEMBL32190 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE n/a
38 P00374_DTT DTT DB04447 439196 CHEMBL406270 2,3-DIHYDROXY-1,4-DITHIOBUTANE n/a
39 P00374_DZF DZF n/a 445175;135460994; n/a 5-DEAZAFOLIC ACID n/a
40 P00374_EDO EDO n/a 174 CHEMBL457299 1,2-ETHANEDIOL n/a
41 P00374_EOH EOH DB00898 702 CHEMBL545 ETHANOL n/a
42 P00374_FOL FOL DB00158 6037;5280354;135398658; CHEMBL1622 FOLIC ACID n/a
43 P00374_G3V G3V n/a 137349387 n/a N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid n/a
44 P00374_G6Y G6Y n/a 124081251 CHEMBL3828485 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid n/a
45 P00374_GI6 GI6 n/a n/a n/a (2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanamide n/a
46 P00374_GOL GOL DB09462 753 CHEMBL692 GLYCEROL n/a
47 P00374_HJI HJI n/a 162540405 n/a (2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid n/a
48 P00374_HXV HXV n/a 162540413 n/a 6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine n/a
49 P00374_HZU HZU n/a n/a n/a (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3-fluoropropanoic acid n/a
50 P00374_I0E I0E n/a 162540399 n/a (2S)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid n/a
51 P00374_I6J I6J n/a 162540409 n/a (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid n/a
52 P00374_IXE IXE n/a 71463580 CHEMBL2382336 N~6~-methyl-N~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine n/a
53 P00374_IXF IXF n/a 71463581 CHEMBL2382332 N~6~-methyl-N~6~-[4-(propan-2-yl)phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine n/a
54 P00374_K K n/a 813 CHEMBL1233793 POTASSIUM ION n/a
55 P00374_LG3 LG3 n/a 67431 CHEMBL1233987 PYRIMIDINE-2,4-DIAMINE n/a
56 P00374_LIH LIH DB03351 446752 CHEMBL151958 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE n/a IC50(nM) = 0.98
57 P00374_LII LII DB03060 446753 n/a (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE n/a
58 P00374_MG MG n/a 888 n/a MAGNESIUM ION n/a
59 P00374_MMV MMV n/a 66563688 CHEMBL3040038 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid n/a
60 P00374_MOT MOT DB02026 158376 CHEMBL104829 N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE n/a
61 P00374_MTX MTX DB00563 126941 CHEMBL34259 METHOTREXATE inhibitor Ki(nM) = 3.4E-4
IC50(nM) = 0.7
Kd(nM) = 0.194984
EC50(nM) = 12.5
62 P00374_MXA MXA DB03695 54369 CHEMBL7492 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE modulator Ki(nM) = 0.025
IC50(nM) = 0.61
63 P00374_NAP NAP DB03461 5885;57525501; CHEMBL295069 NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE n/a
64 P00374_NDP NDP DB02338 5884;134821689; CHEMBL407009 NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE n/a
65 P00374_NH4 NH4 n/a 223;16741146; n/a AMMONIUM ION n/a
66 P00374_NPX NPX n/a 169118 CHEMBL1618254 (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid n/a
67 P00374_OAG OAG n/a 472910 CHEMBL145979 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine n/a
68 P00374_PO4 PO4 DB14523 1061 n/a PHOSPHATE ION n/a
69 P00374_PRD PRD DB02583 444617 CHEMBL32113 N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE n/a IC50(nM) = 26.0
70 P00374_SO4 SO4 DB14546 1117 n/a SULFATE ION n/a
71 P00374_TOP TOP DB00440 5578 CHEMBL22 TRIMETHOPRIM modulator Ki(nM) = 0.006
IC50(nM) = 27.0
72 P00374_TQD TQD DB08642 46937168 n/a (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine n/a
73 P00374_TQT TQT DB02559 17754203 n/a 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE n/a
74 P00374_TRR TRR DB03125 446998;3382784; n/a 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM n/a
75 P00374_VG9 VG9 n/a 457349 CHEMBL279679 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE n/a
76 P00374_SR SR n/a 104798 n/a STRONTIUM ION n/a
77 P00374_NAI NAI DB00157 439153 CHEMBL1234616 NADH n/a
78 P00374_CP6 CP6 DB00205 4993 CHEMBL36 Pyrimethamine inhibitor Ki(nM) = 8.0
IC50(nM) = 400.0
79 P00374_LYA LYA DB00642 446556;5288715;135410875; CHEMBL225072 Pemetrexed inhibitor
80 P00374_DB00798 n/a DB00798 n/a n/a Gentamicin n/a
81 P00374_DB01131 n/a DB01131 n/a n/a Proguanil inhibitor
82 P00374_DB01157 n/a DB01157 n/a n/a Trimetrexate inhibitor Ki(nM) = 0.04
IC50(nM) = 0.42
83 P00374_COG COG DB02427 447021 CHEMBL325434 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline n/a IC50(nM) = 130.0
84 P00374_BIO BIO DB03886 444475;5287790;135449517; n/a Biopterin n/a
85 P00374_COQ COQ DB03987 447022 CHEMBL36245 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine n/a IC50(nM) = 2900.0
86 P00374_DB06358 n/a DB06358 n/a n/a Iclaprim inhibitor
87 P00374_DB06813 n/a DB06813 n/a n/a Pralatrexate substrate
88 P00374_53R 53R DB07140 25093369 CHEMBL459177 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine n/a IC50(nM) = 1360.0
89 P00374_53S 53S DB07141 44144378 CHEMBL575218 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine n/a
90 P00374_53T 53T DB07142 44144379 CHEMBL576960 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine n/a
91 P00374_53V 53V DB07144 44144380 CHEMBL573077 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine n/a
92 P00374_N22 N22 DB08234 25058133 CHEMBL485961 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine n/a IC50(nM) = 1280.0
93 P00374_PMD PMD DB08406 446744 CHEMBL301769 [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE n/a IC50(nM) = 12.0
94 P00374_Q22 Q22 DB08448 46937152 n/a (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol n/a