Ligand name: [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate
PDB ligand accession: 2RC
DrugBank: DB12010
PubChem: 11671467
ChEMBL: CHEMBL2103830
InChI Key: GKDRMWXFWHEQQT-UHFFFAOYSA-N
SMILES: CC1(C(=O)N(c2c(ccc(n2)Nc3c(cnc(n3)Nc4cc(c(c(c4)OC)OC)OC)F)O1)COP(=O)(O)O)C

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Benzenoids
    • Class: Benzene and substituted derivatives
      • Subclass: Aniline and substituted anilines

List of proteins that are targets for DB12010

#	DrugDomain Data	UniProt Accession	Drug Action	Affinity data
1	Q9H422_2RC	Q9H422	inhibitor
2	P06239_2RC	P06239	inhibitor
3	P42345_2RC	P42345	inhibitor
4	P35916_2RC	P35916	inhibitor
5	O43283_2RC	O43283	inhibitor
6	O15197_2RC	O15197	inhibitor
7	P43403_2RC	P43403	inhibitor
8	Q04759_2RC	Q04759	inhibitor
9	Q05397_2RC	Q05397	inhibitor
10	P11802_2RC	P11802	inhibitor
11	P08631_2RC	P08631	inhibitor
12	P42681_2RC	P42681	inhibitor
13	Q6PHR2_2RC	Q6PHR2	inhibitor
14	Q8NG66_2RC	Q8NG66	inhibitor
15	Q9UL54_2RC	Q9UL54	inhibitor
16	Q92772_2RC	Q92772	inhibitor
17	Q9H2X6_2RC	Q9H2X6	inhibitor
18	O60885_2RC	O60885	n/a
19	Q6DT37_2RC	Q6DT37	inhibitor
20	P51812_2RC	P51812	inhibitor
21	O95835_2RC	O95835	inhibitor
22	Q8TD08_2RC	Q8TD08	inhibitor
23	P19784_2RC	P19784	inhibitor
24	Q2M2I8_2RC	Q2M2I8	inhibitor
25	P29376_2RC	P29376	inhibitor
26	O00444_2RC	O00444	inhibitor
27	P42684_2RC	P42684	inhibitor
28	Q9NYL2_2RC	Q9NYL2	inhibitor
29	Q15375_2RC	Q15375	inhibitor
30	Q9NRH2_2RC	Q9NRH2	inhibitor
31	O14578_2RC	O14578	inhibitor
32	Q99759_2RC	Q99759	inhibitor
33	P51957_2RC	P51957	inhibitor
34	Q13131_2RC	Q13131	inhibitor
35	O95819_2RC	O95819	inhibitor
36	Q13523_2RC	Q13523	inhibitor
37	Q86V86_2RC	Q86V86	inhibitor
38	Q9BYT3_2RC	Q9BYT3	inhibitor
39	Q16288_2RC	Q16288	inhibitor
40	O60285_2RC	O60285	inhibitor
41	Q9UQB9_2RC	Q9UQB9	inhibitor
42	P46734_2RC	P46734	inhibitor
43	O00519_2RC	O00519	inhibitor
44	Q9P0L2_2RC	Q9P0L2	inhibitor
45	P21802_2RC	P21802	inhibitor
46	P68400_2RC	P68400	inhibitor
47	O75116_2RC	O75116	inhibitor
48	P29317_2RC	P29317	inhibitor
49	Q9Y2H9_2RC	Q9Y2H9	inhibitor
50	P54756_2RC	P54756	inhibitor
51	Q92918_2RC	Q92918	inhibitor
52	Q9BUB5_2RC	Q9BUB5	inhibitor
53	Q9NRP7_2RC	Q9NRP7	inhibitor
54	Q12852_2RC	Q12852	inhibitor
55	P57078_2RC	P57078	inhibitor
56	Q56UN5_2RC	Q56UN5	inhibitor
57	P22607_2RC	P22607	inhibitor
58	Q02156_2RC	Q02156	inhibitor
59	Q13153_2RC	Q13153	inhibitor
60	Q9UF33_2RC	Q9UF33	inhibitor
61	P53671_2RC	P53671	inhibitor
62	Q9H3Y6_2RC	Q9H3Y6	inhibitor
63	Q14680_2RC	Q14680	inhibitor
64	Q14012_2RC	Q14012	inhibitor
65	Q9BVS4_2RC	Q9BVS4	inhibitor
66	P43405_2RC	P43405	inhibitor
67	Q15139_2RC	Q15139	inhibitor
68	O14730_2RC	O14730	inhibitor
69	O75460_2RC	O75460	inhibitor
70	P09769_2RC	P09769	inhibitor
71	Q99808_2RC	Q99808	inhibitor
72	Q86UE8_2RC	Q86UE8	inhibitor
73	O43353_2RC	O43353	inhibitor
74	P12931_2RC	P12931	inhibitor
75	Q14164_2RC	Q14164	inhibitor
76	Q8IVH8_2RC	Q8IVH8	inhibitor
77	Q04912_2RC	Q04912	inhibitor
78	O00750_2RC	O00750	inhibitor
79	Q9H4B4_2RC	Q9H4B4	inhibitor
80	Q15746_2RC	Q15746	inhibitor
81	Q8IY84_2RC	Q8IY84	inhibitor
82	O15146_2RC	O15146	inhibitor
83	Q7KZI7_2RC	Q7KZI7	inhibitor
84	P51955_2RC	P51955	inhibitor
85	Q8TBX8_2RC	Q8TBX8	inhibitor
86	Q13164_2RC	Q13164	inhibitor
87	Q9UQM7_2RC	Q9UQM7	inhibitor
88	P49759_2RC	P49759	inhibitor
89	P42680_2RC	P42680	inhibitor
90	P17948_2RC	P17948	inhibitor
91	Q02779_2RC	Q02779	inhibitor
92	P54762_2RC	P54762	inhibitor
93	P00533_2RC	P00533	inhibitor
94	Q7L7X3_2RC	Q7L7X3	inhibitor
95	P23458_2RC	P23458	inhibitor
96	P41743_2RC	P41743	inhibitor
97	Q8TDR2_2RC	Q8TDR2	inhibitor
98	Q08881_2RC	Q08881	inhibitor
99	Q9P289_2RC	Q9P289	inhibitor
100	O76074_2RC	O76074	inhibitor
101	Q9NQU5_2RC	Q9NQU5	inhibitor
102	Q96NX5_2RC	Q96NX5	inhibitor
103	P49761_2RC	P49761	inhibitor
104	P35968_2RC	P35968	inhibitor
105	Q96L34_2RC	Q96L34	inhibitor
106	Q52WX2_2RC	Q52WX2	inhibitor
107	Q9UPZ9_2RC	Q9UPZ9	inhibitor
108	P36897_2RC	P36897	inhibitor
109	P11309_2RC	P11309	inhibitor
110	Q9P2K8_2RC	Q9P2K8	inhibitor
111	Q15418_2RC	Q15418	inhibitor
112	Q13557_2RC	Q13557	inhibitor
113	Q9HBH9_2RC	Q9HBH9	inhibitor
114	Q8IW41_2RC	Q8IW41	inhibitor
115	P78356_2RC	P78356	inhibitor
116	O14920_2RC	O14920	inhibitor
117	O15264_2RC	O15264	inhibitor
118	Q05655_2RC	Q05655	inhibitor
119	Q9UK32_2RC	Q9UK32	inhibitor
120	P52333_2RC	P52333	inhibitor
121	Q86YV6_2RC	Q86YV6	inhibitor
122	Q16512_2RC	Q16512	inhibitor
123	Q9P286_2RC	Q9P286	inhibitor
124	Q13627_2RC	Q13627	inhibitor
125	P29597_2RC	P29597	inhibitor
126	Q02763_2RC	Q02763	inhibitor
127	P04626_2RC	P04626	inhibitor
128	P04629_2RC	P04629	inhibitor
129	Q06187_2RC	Q06187	inhibitor
130	P07949_2RC	P07949	inhibitor
131	P17612_2RC	P17612	inhibitor
132	P80192_2RC	P80192	inhibitor
133	P04049_2RC	P04049	inhibitor
134	Q04771_2RC	Q04771	inhibitor
135	Q00537_2RC	Q00537	inhibitor
136	Q8TD19_2RC	Q8TD19	inhibitor
137	P53779_2RC	P53779	inhibitor
138	Q9UIK4_2RC	Q9UIK4	inhibitor
139	P31152_2RC	P31152	inhibitor
140	P06493_2RC	P06493	inhibitor
141	P49841_2RC	P49841	inhibitor
142	Q5S007_2RC	Q5S007	inhibitor
143	Q9HAZ1_2RC	Q9HAZ1	inhibitor
144	Q9Y6E0_2RC	Q9Y6E0	inhibitor
145	P0C264_2RC	P0C264	inhibitor
146	Q9NWZ3_2RC	Q9NWZ3	inhibitor
147	O00238_2RC	O00238	inhibitor
148	O14757_2RC	O14757	inhibitor
149	Q13554_2RC	Q13554	inhibitor
150	Q12866_2RC	Q12866	inhibitor
151	O95747_2RC	O95747	inhibitor
152	O75914_2RC	O75914	inhibitor
153	O14976_2RC	O14976	inhibitor
154	Q08345_2RC	Q08345	inhibitor
155	P16591_2RC	P16591	inhibitor
156	Q13546_2RC	Q13546	inhibitor
157	Q96BR1_2RC	Q96BR1	inhibitor
158	Q9Y2K2_2RC	Q9Y2K2	inhibitor
159	Q14289_2RC	Q14289	inhibitor
160	Q9BXA7_2RC	Q9BXA7	inhibitor
161	P54760_2RC	P54760	inhibitor
162	O75716_2RC	O75716	inhibitor
163	O96013_2RC	O96013	inhibitor
164	P51956_2RC	P51956	inhibitor
165	Q9C098_2RC	Q9C098	inhibitor
166	Q15569_2RC	Q15569	inhibitor
167	Q13237_2RC	Q13237	inhibitor
168	P21709_2RC	P21709	inhibitor
169	Q8NFD2_2RC	Q8NFD2	inhibitor
170	P15056_2RC	P15056	inhibitor
171	P54764_2RC	P54764	inhibitor
172	Q96Q40_2RC	Q96Q40	inhibitor
173	P41240_2RC	P41240	inhibitor
174	Q8NEV4_2RC	Q8NEV4	inhibitor
175	Q8IU85_2RC	Q8IU85	inhibitor
176	Q9Y6R4_2RC	Q9Y6R4	inhibitor
177	O14965_2RC	O14965	inhibitor
178	P07711_2RC	P07711	inhibitor
179	P00519_2RC	P00519	inhibitor
180	P30291_2RC	P30291	inhibitor
181	Q13177_2RC	Q13177	inhibitor
182	O95382_2RC	O95382	inhibitor
183	P53350_2RC	P53350	inhibitor
184	Q9H0K1_2RC	Q9H0K1	inhibitor
185	Q00536_2RC	Q00536	inhibitor
186	P06241_2RC	P06241	inhibitor
187	Q8N568_2RC	Q8N568	inhibitor
188	P53355_2RC	P53355	inhibitor
189	O00329_2RC	O00329	inhibitor
190	P36896_2RC	P36896	inhibitor
191	Q32MK0_2RC	Q32MK0	inhibitor
192	Q8WU08_2RC	Q8WU08	inhibitor
193	P45984_2RC	P45984	inhibitor
194	Q9NSY1_2RC	Q9NSY1	inhibitor
195	Q00532_2RC	Q00532	inhibitor
196	P14616_2RC	P14616	inhibitor
197	O94768_2RC	O94768	inhibitor
198	P11362_2RC	P11362	inhibitor
199	P22694_2RC	P22694	inhibitor
200	P37173_2RC	P37173	inhibitor
201	P57059_2RC	P57059	inhibitor
202	Q13873_2RC	Q13873	inhibitor
203	P06213_2RC	P06213	inhibitor
204	P25774_2RC	P25774	inhibitor
205	P33981_2RC	P33981	inhibitor
206	Q9H093_2RC	Q9H093	inhibitor
207	Q8N4C8_2RC	Q8N4C8	inhibitor
208	P49840_2RC	P49840	inhibitor
209	P42679_2RC	P42679	inhibitor
210	Q6P3R8_2RC	Q6P3R8	inhibitor
211	Q16832_2RC	Q16832	inhibitor
212	P36888_2RC	P36888	inhibitor
213	O75385_2RC	O75385	inhibitor
214	P07332_2RC	P07332	inhibitor
215	Q8N5S9_2RC	Q8N5S9	inhibitor
216	O14936_2RC	O14936	inhibitor
217	P29322_2RC	P29322	inhibitor
218	Q9H2K8_2RC	Q9H2K8	inhibitor
219	P09619_2RC	P09619	inhibitor
220	Q9H2G2_2RC	Q9H2G2	inhibitor
221	O15075_2RC	O15075	inhibitor
222	P07947_2RC	P07947	inhibitor
223	Q13470_2RC	Q13470	inhibitor
224	P05129_2RC	P05129	inhibitor
225	Q59H18_2RC	Q59H18	inhibitor
226	Q16513_2RC	Q16513	inhibitor
227	Q9Y616_2RC	Q9Y616	inhibitor
228	Q9BRS2_2RC	Q9BRS2	inhibitor
229	Q9Y4K4_2RC	Q9Y4K4	inhibitor
230	Q13163_2RC	Q13163	inhibitor
231	Q8IYT8_2RC	Q8IYT8	inhibitor
232	Q06418_2RC	Q06418	inhibitor
233	Q9H1R3_2RC	Q9H1R3	inhibitor
234	P48736_2RC	P48736	inhibitor
235	Q9UM73_2RC	Q9UM73	inhibitor
236	P16234_2RC	P16234	inhibitor
237	Q12851_2RC	Q12851	inhibitor
238	P08922_2RC	P08922	inhibitor
239	P51451_2RC	P51451	inhibitor
240	P07948_2RC	P07948	inhibitor
241	P30530_2RC	P30530	inhibitor
242	Q16816_2RC	Q16816	inhibitor
243	O15530_2RC	O15530	inhibitor
244	P29320_2RC	P29320	inhibitor
245	Q16539_2RC	Q16539	inhibitor
246	P49760_2RC	P49760	inhibitor
247	Q9UKI8_2RC	Q9UKI8	inhibitor
248	Q13233_2RC	Q13233	inhibitor
249	Q99640_2RC	Q99640	inhibitor
250	Q96RR4_2RC	Q96RR4	inhibitor
251	P53667_2RC	P53667	inhibitor
252	Q9Y2U5_2RC	Q9Y2U5	inhibitor
253	Q9UBF8_2RC	Q9UBF8	inhibitor
254	Q9UEW8_2RC	Q9UEW8	inhibitor
255	Q07912_2RC	Q07912	inhibitor
256	O43293_2RC	O43293	inhibitor
257	Q16620_2RC	Q16620	inhibitor
258	O75747_2RC	O75747	inhibitor
259	Q9BQI3_2RC	Q9BQI3	inhibitor
260	P51617_2RC	P51617	inhibitor
261	P29323_2RC	P29323	inhibitor
262	P19525_2RC	P19525	inhibitor
263	O60674_2RC	O60674	inhibitor
264	Q15208_2RC	Q15208	inhibitor
265	Q9Y2H1_2RC	Q9Y2H1	inhibitor
266	P0DMS8_2RC	P0DMS8	antagonist
267	Q96D53_2RC	Q96D53	inhibitor
268	P27448_2RC	P27448	inhibitor
269	P52564_2RC	P52564	inhibitor
270	Q9NYY3_2RC	Q9NYY3	inhibitor
271	Q96GD4_2RC	Q96GD4	inhibitor
272	Q8NI60_2RC	Q8NI60	inhibitor
273	P36507_2RC	P36507	inhibitor
274	P09917_2RC	P09917	inhibitor
275	P35590_2RC	P35590	inhibitor
276	P10721_2RC	P10721	inhibitor
277	P42685_2RC	P42685	inhibitor
278	Q16584_2RC	Q16584	inhibitor
279	Q9UKE5_2RC	Q9UKE5	inhibitor
280	P22309_2RC	P22309	inhibitor
281	Q15303_2RC	Q15303	inhibitor
282	P48729_2RC	P48729	inhibitor
283	Q96PY6_2RC	Q96PY6	inhibitor
284	P08581_2RC	P08581	inhibitor
285	O96017_2RC	O96017	inhibitor
286	Q13188_2RC	Q13188	inhibitor
287	Q13555_2RC	Q13555	inhibitor
288	P07333_2RC	P07333	inhibitor
289	Q9UHD2_2RC	Q9UHD2	inhibitor
290	Q6ZN16_2RC	Q6ZN16	inhibitor
291	O94804_2RC	O94804	inhibitor
292	Q9Y463_2RC	Q9Y463	inhibitor
293	Q13882_2RC	Q13882	inhibitor
294	Q9UEE5_2RC	Q9UEE5	inhibitor
295	P51813_2RC	P51813	inhibitor